Chelsea and Manchester United have been drawn to face each other in the quarter-finals of the Champions League, while Tottenham will play Real Madrid.Barcelona meet Shakhtar Donetsk, with reigning champions Inter Milan drawn against Schalke.
Chelsea or United will go on to face either Inter or Schalke, while the winners of the other two last eight ties will meet in the other semi-final.
The quarter-final ties will be played on 5/6 and 12/13 April.
Chelsea have yet to win the Champions League and will have revenge on their minds after losing the 2008 Champions League final to United on penalties in Moscow.
John Terry famously missed his spot-kick in the shoot-out when he had the chance to win the trophy for the Blues.
The first leg between the Premier League rivals will take place at Stamford Bridge with United, who have won Europe’s top competition three times, at home for the second leg.
“We have a great rivalry domestically but the Champions League is something different,” said Chelsea secretary David Barnard.
“We’re looking forward to it, people will bring up Moscow and revenge but we know each other well enough.
“Most of that team that experienced Moscow are still here so it’ll be a great motivation. We’ve been the bridesmaid many times.”
The tie between Chelsea and United means at least one English team is guaranteed a place in the semi-finals of the Champions League and the chance to make it to the final at Wembley on 28 May.
Whoever does win will play the first leg of their semi-final against inter or Schalke away with the return at home.
United secretary John Alexander said: “It’s a shame the English clubs were paired together. We have a good record against domestic clubs in Europe and I’m sure [manager] Sir Alex [Ferguson] will be prepared.
“It’s a great chance for whoever comes through to make it to Wembley. Most teams wanted to avoid a clash with Barcelona.”
Spurs knocked out AC Milan in the last round and will travel to the Bernabeu for the first leg of their tie against Real Madrid before hosting the nine-time winners at White Hart Lane in the second leg.
â€œIt really is a dream tie for us, they’ve won this competition more than anyone else,” said Darren Eales, Spurs director of football administration. “It’s a game of football so anything can happen.”
The two clubs met in the quarter-finals of the 1984/85 Uefa Cup when the Spanish side won 1-0 at Tottenham before a goalless draw at the Bernabeu helped them advance on the way to winning the trophy that season.
But Real have failed to win their last five Champions League encounters against English clubs and have lost four of those games.
Tottenham, who reached the European Cup semi-finals in 1962 when they lost to Benfica, will be out to stop Real manager Jose Mourinho’s attempts to become the first man to win the Champions League with three different clubs.
Mourinho led Porto to glory in the competition in 2004 and guided Inter to victory last season before making the switch from the San Siro to Spain.
He has ended a run of Real Madrid failing to make it through to the last eight since 2004, with their last win in the Champions League coming in 2002.
Mourinho said: “I’m happy not because it is easy but because I love to play in England.”
Real Madrid director Emilio Butragueno added: “We are very happy because over the last few seasons we have been unable to get to this round.
“This competition is the most prestigious in Europe. It is going to be a fantastic tie and Tottenham have great great players, offensive players and are very competitive.
“I’m sure it’s going to be very difficult for us. I’m hopeful our team will rise to the occasion.”
Spurs signed playmaker Rafael van der Vaart from Real last summer and Butragueno said: “Rafael van der Vaart is a fantastic player and a great person and professional and I’m happy he’s been very successful.
“I’m sure he’ll strive to do a great game and help his team qualify for the semi-finals.”
The tie between them promises goals as Tottenham, managed by Harry Redknapp, and Real have scored the most goals of the remaining teams with 19 apiece, although the Spanish outfit have let in only three while Spurs have conceded 11.
If Spurs do progress they have been drawn to be at home for the first leg of a potential semi-final against favourites Barcelona or last eight debutants Shakhtar and away for the second leg.
Real and United are the only unbeaten teams left in this season’s competition while Inter have lost three games, which is the most of any of the clubs contesting the quarter-finals.
CHAMPIONS LEAGUE Q/F DRAW
Real Madrid v TOTTENHAM
CHELSEA v MAN UTD
Barcelona v Shakhtar Donetsk
Inter Milan v Schalke 04
Ties to be played on 5/6 and 12/13 April.
CHAMPIONS LEAGUE S/F DRAW
Inter Milan/Schalke 04 v CHELSEA/MAN UTD
Real Madrid/TOTTENHAM v Barcelona/Shakhtar Donetsk
Ties to be played on 26/27 April and 3/4 May.