Nine other passengers sustained serious injuries and are being treated at Rusape General Hospital.
Manicaland police spokesperson, Inspector Leonard Chabata confirmed the accident which occurred near Rusape.
Inspector Chabata urged motorists to desist from speeding and to abide by road regulations.
The commuter omnibus which was carrying 23 passengers was coming from Mutare heading to Harare.
The accident comes barely four days after another horrific accident also involving a commuter omnibus claimed 19 lives along the Harareâ€“Concession highway.